Epstein-Barr Virus

Additional Info

  • CPT Code(s)***: 88365 (Global); 88365TC (Technical Component Only)
  • Methodology: In Situ Hybridization (ISH)
  • Specimen Requirements: 5 formalin-fixed (10% neutral buffered formalin), paraffin-embedded tissue sections on "plus" (positively) charged slides or a paraffin tissue block.
  • Shipping Instructions: Ship blocks with cold pack. Ship formalin-fixed, paraffin-embedded tissue with an absorbent, secondary containment pack.
  • Clinical Utility: Epstein-Barr virus (EBV) is a member of the herpes virus family and is associated with a variety of pathological conditions including infectious mononucleosis, Burkitt's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma. In HIV patients, EBV presents as primary central nervous system lymphomas and oral hairy leukoplakia lesions. Epstein Barr Virus (EBV) plays a significant role as a cofactor in the process of tumorigenesis and has consistently been associated with a variety of malignancies. EBV infection is established in most individuals prior to HIV infection.
  • Turnaround Time: 24-36 Hours
  • ***: CPT codes are based on American Medical Association guidelines and are for informational purposes only. The billing party is responsible for CPT coding.