Human Papilloma Virus High Risk (HPV-H)

Additional Info

  • CPT Code(s)***: 88365 (Global); 88365TC (Technical Component Only)
  • Methodology: In Situ Hybridization (ISH)
  • Specimen Requirements: 5 formalin-fixed (10% neutral buffered formalin), paraffin-embedded tissue sections on "plus" (positively) charged slides or a paraffin tissue block.
  • Shipping Instructions: Ship blocks with cold pack. Ship formalin-fixed, paraffin-embedded tissue with an absorbent, secondary containment pack.
  • Clinical Utility: Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. HPV is the causative agent of cervical dysplasia and carcinoma and is also a risk factor for anal carcinoma and oropharyngeal carcinoma. Most women infected with high-risk genital HPV do not develop cancer and often clear the infection, usually within 2 years. HPV is fequently asymptomatic but may present with genital warts. Selected high-risk subtypes are assessed in tissue block.
  • Turnaround Time: 24-36 Hours
  • ***: CPT codes are based on American Medical Association guidelines and are for informational purposes only. The billing party is responsible for CPT coding.